p75NTR in Huntington's disease: beyond the basal ganglia

p75NTR in Huntington's disease: beyond the basal ganglia

Huntington's disease (HD) is a fatal neurodegenerative disorder with a characteristic phenotype including chorea and dystonia, uncoordinated fine movements, cognitive decline and psychiatric disturbances. Even though the clinical diagnosis of HD relies on the manifestation of motor abnormalities, the associated memory impairments have been growing in prominence. Indeed, cognitive deficits are e...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Beyond the Basal Ganglia Widespread pathology in Huntington’s disease

Beyond the Basal Ganglia, widespread pathology in Huntington's disease Huntington's disease (HD) is a fatal, hereditary disorder caused by a mutation in the gene encoding the protein huntingtin. Although mutant huntingtin is ubiquitously expressed throughout the body, HD research has mainly focused on the role of the basal ganglia. Dysfunction of these brain nuclei likely underlies motor distur...

fahr disease: idiopathic basal ganglia calcification

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Oscillations and the basal ganglia: Motor control and beyond

Oscillations form a ubiquitous feature of the central nervous system. Evidence is accruing from cortical and sub-cortical recordings that these rhythms may be functionally important, although the precise details of their roles remain unclear. The basal ganglia share this predilection for rhythmic activity which, as we see in Parkinson's disease, becomes further enhanced in the dopamine depleted...